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Tyler Hill led the Panthers offensively with 19 points, including 10-11 from the charity stripe.
Austin Exum had eight points and a strong defensive and rebounding effort.
Seybian Holt added five points and Matt Gibbons scored four and led the Panthers in rebounding.
The Panthers entered the fourth quarter up by six, but went on a 10-0 run to pull away from the Leopards.
They play again on Monday as they travel to Atlanta.